The effects of the study drugs will be evaluated in the following predefined subgroups of patients:
Age (above/below the median value) |
Left ventricular function (EF% >40% vs =<40%) |
Etiology (ischemic vs non-ischemic) |
Functional capacity (NYHA class II vs III-IV) |
Diabetes (yes vs no) |
Baseline total cholesterol levels (above/below the median value) |
Patients with preserved LV function (EF >40%) will be further stratified in 2 subgroups with and without probable diastolic heart failure according to the criteria by Vasan.
The end-point for all the subgroup analyses is the combined outcome measure of all-cause mortality or hospital admission for cardiovascular reasons.
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