Gissi > Gissi 1 > Introduzione
GISSI
Original GISSI 1 Logo
Newsletter Contattaci (e-mail e indirizzi)
Login per i medici del Gissi
GISSI Home Page Actual GISSI project - GISSI Heart Failure Other GISSI Projects Other Links
 

Protocol

Introduction

The therapy

The n-3 PUFA hypothesis

The statin hypothesis

Study design

Primary objectives

Other end-point measures of efficacy

Subgroup analysis

Mechanistic goals

Concomitant treatments

Sample size calculation

Main analyses

References
  Subgroup analysis


The effects of the study drugs will be evaluated in the following predefined subgroups of patients:

Age (above/below the median value)
Left ventricular function (EF% >40% vs =<40%)
Etiology (ischemic vs non-ischemic)
Functional capacity (NYHA class II vs III-IV)
Diabetes (yes vs no)
Baseline total cholesterol levels (above/below the median value)

Patients with preserved LV function (EF >40%) will be further stratified in 2 subgroups with and without probable diastolic heart failure according to the criteria by Vasan.

The end-point for all the subgroup analyses is the combined outcome measure of all-cause mortality or hospital admission for cardiovascular reasons.