The difference in survival produced by streptokinase and sustained up to one year was still significant at 10 years (log-rank test: p=0.02) with the absolute benefit of 19 (95%CI: 1 to 37) lives saved per 1000 patients treated.
In the overall population, most of the benefit was obtained before hospital discharge (RR 0.81, 95%CI 0.72-0.90), since no difference in survival between thrombolyzed and control patients discharged alive was found at 10 years (RR 0.98, 95%CI 0.90-1.06).
A slight albeit non significant divergence of the survival curves of patients randomized within the first hour was observed [90 (95%CI: 34 to 146) lives saved per 1000 at 10 years versus 72 (95%CI: 37 to 107) lives saved at hospital discharge].
