Evaluation of the efficacy of a treatment with ACE-inhibitors and/or nitrates on 6-week mortality following acute myocardial infarction (AMI); evaluation of the extent to which such a favourable effect on left ventricular function (measured at 6 weeks), if present, is maintained up to 6 months following the event. The evaluation is carried out on the combined endpoint of mortality and left ventricular damage.
Open controlled clinical trial with central randomisation of patients following a 2x2 factorial design to treatment with lisinopril, nitrate, both or neither within 24 hours of initial symptoms. Treatments are administered for 6 weeks.
19.394 patients in 24 months, from June 1991 or July 1993. The study was preceded by a pilot phase on 1526 patients.